Hvordan kan det danske og norske Forsvaret forbedre organisationens evne til at opsamle, integrere og dele den viden, som genereres af personellet

Masterprosjekt i IKT og Læring.Det danske og det norske forsvar bruger begge erfaringshåndteringssystemer, for at kunne fastholde erfaringer fra bl.a. internationale missioner. I Norge hedder systemet FERDABALL, i Danmark er navnet DLIMS. Formålet er, at kunne anvende den fastholdte viden til at forbedre kapaciteten i fremtidige missioner, og undgå at de samme fejl bliver gentaget. Indholdet af databaserne er data og informationer, som er baseret på den viden, der bliver oparbejdet gennem de erfaringer missionens deltager gør sig. Analysen af begge erfaringshåndteringssystemer har vist, at begge indeholder mangelfulde data, at personellet er dårligt uddannet i brug af systemerne og at de har ringe kendskab til formålet. Det betyder, at der er viden og erfaringer, som forbliver usynlige for organisationen. I denne opgave ser vi på, hvordan vi kan øge den organisatoriske værdi af de erfaringer den enkelte soldat har gjort under sin deltagelse i missioner. Gennem interview i Danmark og fokusgruppeinterview i Norge har vi kvalificeret analysen. Resultaterne antyder, at forslag der skal øge den organisatoriske værdi af erfaringerne skal følge tre retninger. Til at indsamle data og informationer vil vi præsentere en APP, som er designet til af forbedre den enkelte soldats muligheder for at bidrage med tekst, billeder, video og audio. For selve vidensdelingssystemet med den tilhørende database forelsår vi en mere wiki orienteret tilgang til analyse og opbevaring af data, informationer og viden. Og endelig for distributionen af vidensdatabasens indhold ser vi på en mere Google inspireret søgemotor, som tillader den enkelte en langt lettere tilgang til den eksplicitte viden der er lagtet i FERDABALL og i DLIMS

Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults

BACKGROUND: Exposure to particulate matter (PM) is generally associated with elevated risk of cardiovascular morbidity and mortality. Elderly and obese subjects may be particularly susceptible, although short-term effects are poorly described. METHODS: Sixty healthy subjects (25 males, 35 females, age 55 to 83 years, body mass index > 25 kg/m(2)) were included in a cross-over study with 5 hours of exposure to particle- or sham-filtered air from a busy street using an exposure-chamber. The sham- versus particle-filtered air had average particle number concentrations of ~23.000 versus ~1800/cm(3) and PM(2.5) levels of 24 versus 3μg/m(3), respectively. The PM contained similar fractions of elemental and black carbon (~20-25%) in both exposure scenarios. Reactive hyperemia and nitroglycerin-induced vasodilation in finger arteries and heart rate variability (HRV) measured within 1 h after exposure were primary outcomes. Potential explanatory mechanistic variables included markers of oxidative stress (ascorbate/dehydroascorbate, nitric oxide-production cofactor tetrahydrobiopterin and its oxidation product dihydrobiopterin) and inflammation markers (C-reactive protein and leukocyte differential counts). RESULTS: Nitroglycerin-induced vasodilation was reduced by 12% [95% confidence interval: −22%; −1.0%] following PM exposure, whereas hyperemia-induced vasodilation was reduced by 5% [95% confidence interval: −11.6%; 1.6%]. Moreover, HRV measurements showed that the high and low frequency domains were significantly decreased and increased, respectively. Redox and inflammatory status did not change significantly based on the above measures. CONCLUSIONS: This study indicates that exposure to real-life levels of PM from urban street air impairs the vasomotor function and HRV in overweight middle-aged and elderly adults, although this could not be explained by changes in inflammation, oxidative stress or nitric oxide-cofactors. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12989-015-0081-9) contains supplementary material, which is available to authorized users

A GNSS velocity field for geophysical applications in Fennoscandia

In Fennoscandia, tectonics, Glacial Isostatic Adjustment (GIA), and climatic changes cause ongoing crustal deformation of some millimetres per year, both vertically and horizontally. These displacements of the Earth can be measured to a high degree of precision using a Global Navigation Satellite System (GNSS). Since about three decades, this is the major goal of the Baseline Inferences for Fennoscandian Rebound, Sea-level, and Tectonics (BIFROST) project. We present a new velocity field for an extended BIFROST GNSS network in the ITRF2008 reference frame making use of the GNSS processing package GPS Analysis Software of MIT (GAMIT). Compared to earlier publications, we have almost doubled the number of stations in our analysis and increased the observation time span, thereby avoiding the early years of the network with many instrument changes. We also provide modelled vertical deformation rates from contributing processes, i.e. elastic deformation due to global atmospheric and non-tidal ocean loading, ice mass and hydrological changes as well as GIA. These values for the vertical component can be used for removal of these contributions so that the residual uplift signal can be further analysed, e.g., in the context of local or regional deformation processes or large-scale but low-magnitude geodynamics. The velocity field has an uplift maximum of 10.3 mm/yr in northern Sweden west of the Gulf of Bothnia and subsidence exceeding 1 mm/yr in northern Central Europe. The horizontal velocity field is dominated by plate motion of more than 20.0 mm/yr from south-west to north-east. The elastic uplift signal sums up to 0.7–0.8 mm/yr for most stations in Northern Europe. Hence, the maximum uplift related to the past glaciation is ca. 9.6 mm/yr. The residual uplift signal after removal of the elastic and GIA contribution may point to possible improvements of the GIA model, but may also indicate regional tectonic and erosional processes as well as local deformation effects. We show an example of such residual signal discussing potential areas of interest for further studies

L1-CAM expression in ccRCC correlates with shorter patients survival times and confers chemoresistance in renal cell carcinoma cells

Conflicting data exist about the expression of L1 cell adhesion molecule (L1-CAM) in clear cell renal cell carcinoma (ccRCC). To determine the clinical usefulness of L1-CAM as a therapeutic or prognostic marker molecule in renal cancer patients, we analyzed its expression on a cohort of 282 renal cell carcinoma (RCC) patients. L1-CAM expression was found in 49.5% of 282 renal cancer tissues. Importantly, L1-CAM expression in patients with ccRCC was associated with significantly shorter patient survival time. We further present evidence that L1-CAM was involved in the resistance against therapeutic reagents like rapamycin, sunitinib and cisplatin. The downregulation of L1-CAM expression decreased renal cancer cell proliferation and reduced the expression of cyclin D1. In addition, we found out that Von Hippel-Lindau (VHL) deficiency was accompanied by a downregulation of the transcription factor PAX8 and L1-CAM. In normal renal tissue, PAX8 and L1-CAM were co-expressed in collecting duct cells. Importantly, the downregulation of PAX8 by small interfering RNA increased the expression of L1-CAM and concomitantly induced the migration of renal cancer cells. Furthermore, we observed in 65.3% of 282 RCC patients a downregulation of PAX8 expression. With chromatin immunoprecipitation analysis, we additionally demonstrate that PAX8 can bind to the promoter of L1-CAM and we further observed that the downregulation of PAX8 was accompanied by increased L1-CAM expression in a high fraction of ccRCC patients. In summary, we show that VHL and PAX8 are involved in the regulation of L1-CAM in renal cancer and L1-CAM represents an important therapeutic and prognostic marker protein for the treatment of ccRC

Down-regulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer

BACKGROUND: Decreased expression of the interferon-stimulated, putative tumour suppressor gene XAF1 has been shown to play a role during the onset, progression and treatment failure in various malignancies. However, little is yet known about its potential implication in the tumour biology of clear-cell renal cell cancer (ccRCC). METHODS: This study assessed the expression of XAF1 protein in tumour tissue obtained from 291 ccRCC patients and 68 normal renal tissue samples, utilizing immunohistochemistry on a tissue-micro-array. XAF1 expression was correlated to clinico-pathological tumour features and prognosis. RESULTS: Nuclear XAF1 expression was commonly detected in normal renal- (94.1%) and ccRCC (91.8%) samples, without significant differences of expression levels. Low XAF1 expression in ccRCC tissue, however, was associated with progression of tumour stage (p = 0.040) and grade (p < 0.001). Low XAF1 tumour levels were also prognostic of significantly shortened overall survival times in univariate analysis (p = 0.018), but did not provide independent prognostic information. CONCLUSION: These data suggest down-regulation of XAF1 expression to be implicated in ccRCC progression and implies that its re-induction may provide a therapeutic approach. Although the prognostic value of XAF1 in ccRCC appears to be limited, its predictive value remains to be determined, especially in patients with metastatic disease undergoing novel combination therapies of targeted agents with Interferon-alpha

Anmeldelser

Anmeldelser af:Erik Fischer, Michael B&oslash;gh Rasmussen, Ernst Jonas Bencard: Melchior Lorck. Bd. 1-4. Forlaget Vandkunsten, 2009.Ulrik Langen: Den afm&aelig;gtige &ndash; en biografi om Christian 7. Jyllands-Postens Forlag, 2008. 542 s., ill.Palle Thilo: Orlogsbriggen Lougen, 18 kanoner, 1791-1802.Forlaget Falcon, 2009. 169 s., ill.Kjeld Hansen: Det tabte land. Den store fort&aelig;lling om magten over det danske landskab. Gads Forlag, 2008. 847 s., ill.Anette Faye Jacobsen: Husbondret. Rettighedskulturer i Danmark 1750-1920. Museum Tusculanums Forlag, 2008. 574 s.Poul Ulrich Jensen: Byens plan. Vejles fysiske udvikling 1786-2007. Vejles Historie bd. 5. Vejle Kommune, 2007. 250 s., ill.Gerda Bonderup, J&oslash;rgen Mikkelsen og Lisbeth Skjernov (red.): &bdquo;af yderste Vigtighed for det hele Borgersamfunds Tryghed&ldquo;. Medicinalberetninger og deres anvendelsesmuligheder i historisk forskning. Kildeskriftselskabet, 2005. 491 s

Baryon Acoustic Oscillations and Dynamical Dark Energy

We compute the impact of dark energy at last scattering on measurements of baryon acoustic oscillations (BAOs). We show that an early dark energy component can contribute a systematic uncertainty to BAO measurements of up to 2.5%. Whilst this effect turns out to only slightly affect current BAO surveys, the results of future BAO surveys might become biased. We find that BAO surveys alone appear unable to resolve this systematic uncertainty, so supplementary measurements are necessary.Comment: 4 pages, added sections and references, matches published versio

Senicapoc treatment in COVID-19 Patients with Severe Respiratory Insufficiency - A Randomized, Open-Label, Phase II Trial

BACKGROUND: The aim of the current study was to determine if treatment with senicapoc, improves the PaO(2)/FiO(2) ratio in patients with COVID‐19 and severe respiratory insufficiency. METHODS: Investigator‐initiated, randomized, open‐label, phase II trial in four intensive care units (ICU) in Denmark. We included patients aged ≥18 years and admitted to an ICU with severe respiratory insufficiency due to COVID‐19. The intervention consisted of 50 mg enteral senicapoc administered as soon as possible after randomization and again after 24 h. Patients in the control group received standard care only. The primary outcome was the PaO(2)/FiO(2) ratio at 72 h. RESULTS: Twenty patients were randomized to senicapoc and 26 patients to standard care. Important differences existed in patient characteristics at baseline, including more patients being on non‐invasive/invasive ventilation in the control group (54% vs. 35%). The median senicapoc concentration at 72 h was 62.1 ng/ml (IQR 46.7–71.2). The primary outcome, PaO(2)/FiO(2) ratio at 72 h, was significantly lower in the senicapoc group (mean 19.5 kPa, SD 6.6) than in the control group (mean 24.4 kPa, SD 9.2) (mean difference −5.1 kPa [95% CI −10.2, −0.04] p = .05). The 28‐day mortality in the senicapoc group was 2/20 (10%) compared with 6/26 (23%) in the control group (OR 0.36 95% CI 0.06–2.07, p = .26). CONCLUSIONS: Treatment with senicapoc resulted in a significantly lower PaO(2)/FiO(2) ratio at 72 h with no differences for other outcomes

A qualitative assessment of implementing a cross-cultural survey on cancer wards in Denmark - a description of barriers

<p>Abstract</p> <p>Background</p> <p>Research into migration and health is often confronted with methodological challenges related to the identification of migrants in various settings. Furthermore, it is often difficult to reach an acceptable level of participation among migrant groups in quantitative research. The aim of this study is to conduct a qualitative assessment of the barriers encountered during the implementation of a cross-cultural survey on cancer wards in Copenhagen, Denmark.</p> <p>Methods</p> <p>Participant observation at the involved wards was combined with qualitative interviews with selected nurses and informal talks with a wider group of nurses at the wards involved in the survey.</p> <p>Results</p> <p>One possible way to increase the participation of migrant patients in research is through the involvement of the hospital staff in contact with patients. Involvement of nurses on cancer wards in the delivery of questionnaires to patients was challenging, despite a general willingness to participate in psychosocial research. The main difficulties were found to be both external (policy changes, general strike among nurses) and internal on the wards (heavy workload, lack of time, focus on medical aspects of cancer rather than psychosocial aspects). These factors interacted and resulted in a lower priority being given to psychosocial research. Further, nurses expressed a feeling that researchers in general did not recognize their contribution in research, making it more difficult to engage fully in studies.</p> <p>Conclusions</p> <p>Involving hospital staff in research is feasible but not straightforward. Awareness of the influence of possible external and internal factors and efforts to deal with these factors are fundamental to the successful implementation of psychosocial cancer research in a hospital setting.</p

Magnitude, frequency and climate forcing of global volcanism during the last glacial period as seen in Greenland and Antarctic ice cores (60–9 ka)

Large volcanic eruptions occurring in the last glacial period can be detected by their accompanying sulfuric acid deposition in continuous ice cores. Here we employ continuous sulfate and sulfur records from three Greenland and three Antarctic ice cores to estimate the emission strength, the frequency and the climatic forcing of large volcanic eruptions that occurred during the second half of the last glacial period and the early Holocene, 60–9 kyr before 2000 CE (b2k). Over most of the investigated interval the ice cores are synchronized, making it possible to distinguish large eruptions with a global sulfate distribution from eruptions detectable in one hemisphere only. Due to limited data resolution and large variability in the sulfate background signal, particularly in the Greenland glacial climate, we only list Greenland sulfate depositions larger than 20 kg km−2 and Antarctic sulfate depositions larger than 10 kg km−2. With those restrictions, we identify 1113 volcanic eruptions in Greenland and 737 eruptions in Antarctica within the 51 kyr period – for which the sulfate deposition of 85 eruptions is found at both poles (bipolar eruptions). Based on the ratio of Greenland and Antarctic sulfate deposition, we estimate the latitudinal band of the bipolar eruptions and assess their approximate climatic forcing based on established methods. A total of 25 of the identified bipolar eruptions are larger than any volcanic eruption occurring in the last 2500 years, and 69 eruptions are estimated to have larger sulfur emission strengths than the Tambora, Indonesia, eruption (1815 CE). Throughout the investigated period, the frequency of volcanic eruptions is rather constant and comparable to that of recent times. During the deglacial period (16–9 ka b2k), however, there is a notable increase in the frequency of volcanic events recorded in Greenland and an obvious increase in the fraction of very large eruptions. For Antarctica, the deglacial period cannot be distinguished from other periods. This confirms the suggestion that the isostatic unloading of the Northern Hemisphere (NH) ice sheets may be related to the enhanced NH volcanic activity. Our ice-core-based volcanic sulfate records provide the atmospheric sulfate burden and estimates of climate forcing for further research on climate impact and understanding the mechanism of the Earth system